Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

930237

Sigma-Aldrich

2,5-dioxopyrrolidin-1-yl (2,5-dichlorobenzoyl)glycyl-L-leucinate

≥95%

Synonym(s):

CANDDY_MLN Tag NHS ester

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H21Cl2N3O6
Molecular Weight:
458.29
UNSPSC Code:
12352209
NACRES:
NA.21

Quality Level

100

Assay

≥95%

form

powder

storage temp.

2-8°C

SMILES string

ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1

Related Categories

Application

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service