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927708

Sigma-Aldrich

2,2,11-trimethyl-4-oxo-3,8-dioxa-5,11-diazatetradecan-14-oic acid

≥95%

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About This Item

Empirical Formula (Hill Notation):
C13H26N2O5
Molecular Weight:
290.36
UNSPSC Code:
12352106
NACRES:
NA.21

Quality Level

100

Assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

carboxylic acid
ester

storage temp.

2-8°C

Application

2,2,11-trimethyl-4-oxo-3,8-dioxa-5,11-diazatetradecan-14-oic acid is a heterobifunctional crosslinker useful for development of PROTAC degraders for targeted protein degradation or other bifunctional molecules in chemical biology. Incorporation of rigidity into the linker region may impact the 3D orientation of the molecules and thus ternary complex formation as well as optimization of drug-like properties. For linkers already conjugated to E3 ligase ligands, please visit our collection of Protein Degrader Building Blocks.

Other Notes

Technology Article: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks Portal

Crosslinkers for Bioconjugation

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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