910066
6-(2-(2-(Oct-7-yn-1-yloxy)ethoxy)ethoxy)hexanoic acid
≥90%
Synonym(s):
6-2-2-6 PROTAC® linker, Alkyne-PEG3-acid, Bifunctional linker
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About This Item
Empirical Formula (Hill Notation):
C18H32O5
Molecular Weight:
328.44
UNSPSC Code:
12352106
Assay
≥90%
form
liquid
reaction suitability
reagent type: linker
functional group
alkyne
carboxylic acid
storage temp.
2-8°C
SMILES string
OC(CCCCCOCCOCCOCCCCCCC#C)=O
Application
This heterobifunctional, PEGylated crosslinker 6-(2-(2-(oct-7-yn-1-yloxy)ethoxy)ethoxy)hexanoic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG3-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation where the linker region is referred to as 6-2-2-6.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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