910058
2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid
≥95%
Synonym(s):
2-2-6 PROTAC® linker, Alkyne-PEG2-acid, Bifunctional linker
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About This Item
Empirical Formula (Hill Notation):
C12H20O4
Molecular Weight:
228.28
UNSPSC Code:
12352106
Assay
≥95%
form
(Viscous Liquid or Semi-solid or Paste or Solid)
reaction suitability
reaction type: click chemistry
reagent type: linker
functional group
alkyne
carboxylic acid
storage temp.
2-8°C
SMILES string
OC(COCCOCCCCCCC#C)=O
Application
This heterobifunctional, PEGylated crosslinker 2-(2-(oct-7-yn-1-yloxy)ethoxy)acetic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG2-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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