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Merck

Enantioselective total synthesis of the indole alkaloid 16-episilicine.

Chemical communications (Cambridge, England) (2009-05-14)
Mercedes Amat, Begoña Checa, Núria Llor, Elies Molins, Joan Bosch
RESUMEN

The first total synthesis of (-)-16-episilicine has been completed from a phenylglycinol-derived bicyclic lactam, the key steps being stereoselective conjugate addition and alkylation reactions, and a ring-closing metathesis.

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Sigma-Aldrich
N-(2-Hydroxyethyl)aniline, 98%