V900890

Estroptozocina

Vetec^™, reagent grade, 98%, powder

• Sinónimos: N-(Metilnitrosocarbamoil)-α-D-glucosamina, Estreptozotocina
• Fórmula empírica (notación de Hill): C₈H₁₅N₃O₇
• Número de CAS: 18883-66-4
• Peso molecular: 265.22
• Beilstein/REAXYS Number: 2060675
• MDL number: MFCD00006607
• UNSPSC Code: 12352200
• PubChem Substance ID: 329830222

Propiedades

• grade: reagent grade
• product line: Vetec^™
• assay: 98%
• form: powder
• mp: 121 °C (dec.) (lit.)
• storage temp.: −20°C
• SMILES string: CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
• InChI: 1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
• InChI key: ZSJLQEPLLKMAKR-GKHCUFPYSA-N

Descripción

General description

Streptozocin (STZ or 2-deoxy-2(3-methyl-3-nitrosoureido)-d-glucopyranose), an antibiotic, is primarily isolated from Streptomyces achromogenes.

Application

Streptozocin has been used:

• to treat mice intraperitoneally for the animal experiments
• in sodium citrate buffer to treat mice intraperitoneally for in vivo STZ treatment to perform single-cell RNA sequencing of pancreatic endocrine cells
• to induce diabetes/diabetic retinopathy (DR) in mice to study the role of microglial spleen tyrosine kinase (Syk) in DR

Biochem/physiol Actions

Compuesto N-nitroso que actúa como donante de óxido nítrico en los islotes pancreáticos; induce la muerte de las células secretoras de insulina, produciendo un modelo animal de diabetes. Potente agente metilante del ADN que induce la rotura cromosómica. Citotóxico para las líneas celulares tumorales neuroendocrinas que expresan el transportador de glucosa GLUT2.

Streptozocin (STZ or 2-deoxy-2(3-methyl-3-nitrosoureido)-d-glucopyranose), a potent alkylating agent, resulting in pancreatic β-cell destruction, is used as an agent to induce insulin-dependent diabetes mellitus (IDDM) experimentally. It exhibits oncolytic, anti-tumor, oncogenic, and diabetogenic properties. This antineoplastic agent is used in the treatment of metastatic pancreatic islet cell carcinoma. STZ can directly methylate DNA and is highly genotoxic.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS08
• signalword: Warning
• hcodes: H228,H341,H351
• pcodes: P201 - P202 - P210 - P240 - P241 - P308 + P313
• Hazard Classifications: Carc. 2 - Flam. Sol. 2 - Muta. 2
• Storage Class: 4.1B - Flammable solid hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable