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X4879

Sigma-Aldrich

Xaliproden

≥97% (HPLC), solid

Sinónimos:

1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride, SR-57746A

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About This Item

Fórmula empírica (notación de Hill):
C24H22F3N · HCl
Número de CAS:
90494-79-4
Peso molecular:
417.89
MDL number:
MFCD00896209
UNSPSC Code:
12352200
PubChem Substance ID:
329830807
NACRES:
NA.77

Quality Level

100

assay

≥97% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: ≥5 mg/mL

originator

Sanofi Aventis

storage temp.

2-8°C

SMILES string

Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2

InChI

1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H

InChI key

WVHBEIJGAINUBW-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

Biochem/physiol Actions

5-HT1A serotonin receptor agonist; neuroprotectant

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Marc Porzner et al.
Expert opinion on investigational drugs, 18(11), 1765-1772 (2009-10-10)
Neurodegenerative disorders such as Alzheimer's disease or amyotrophic lateral sclerosis as well as peripheral neuropathies are difficult to treat due to a limited range of effective drugs. Neurotrophic growth factors promote neuronal survival and differentiation and could hence be interesting
G S Ruigt et al.
Neuroscience letters, 203(1), 9-12 (1996-01-12)
A co-culture system of intact rat dorsal root ganglia (DRG) with Schwann cells was used to evaluate the potential neurotrophic activity of SR 57746A. Neuritogenesis from DRG was measured with an image analysis system following exposure to different concentrations of
A Appert-Collin et al.
International journal of immunopathology and pharmacology, 18(2), 233-244 (2005-05-13)
Neurotrophic growth factors are involved in cell survival. However, natural growth factors have a very limited therapeutic use because of their short half-life. In the present study, we investigated the mechanism of action of a non-peptidic neurotrophic drug, Xaliproden, a
Xaliproden lessens oxaliplatin-mediated neuropathy.
Ed Susman
The Lancet. Oncology, 7(4), 288-288 (2006-04-08)
J Fournier et al.
The Journal of pharmacy and pharmacology, 50(3), 323-327 (1998-05-26)
SR 57746A (1-(2beta-naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,5,6 -tetrahydropyridine hydrochloride) is a neuroprotective compound which potentiates nerve-growth factor (NGF)-induced differentiation in PC12 cells. We have evaluated the interaction of SR 57746A with the other members of the neurotrophin family in this cell-line. In contrast with
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