T8325
TDZD-8
≥98% (HPLC), needles
Sinónimos:
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
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About This Item
Fórmula empírica (notación de Hill):
C10H10N2O2S
Número de CAS:
Peso molecular:
222.26
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Quality Level
assay
≥98% (HPLC)
form
needles
storage condition
protect from light
color
white
mp
63-64.4 °C
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
CN1SC(=O)N(Cc2ccccc2)C1=O
InChI
1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChI key
JDSJDASOXWCHPN-UHFFFAOYSA-N
Application
TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.
Biochem/physiol Actions
TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.
Features and Benefits
This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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