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Merck
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Key Documents

T3705

Sigma-Aldrich

Transferrin human

Optiferrin™, recombinant, expressed in rice

Sinónimos:

Optiferrin™

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About This Item

Número de CAS:
11096-37-0
EC Number:
234-318-8
MDL number:
MFCD00132442
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

human

Quality Level

200

recombinant

expressed in rice

assay

≥95% (agarose gel electrophoresis)

form

powder

composition

Protein, ≥90%

Iron content

≥300 μg/g

technique(s)

immunoprecipitation (IP): suitable
tissue culture: suitable

impurities

≤1.0 EU/mg Endotoxin

UniProt accession no.

P02787

storage temp.

−20°C

Gene Information

human ... TF(7018)

General description

Transferrin is an 80 kDa serum glycoprotein, which is expressed in hepatocytes. The gene is located on human chromosome 3q22.1.
Optiferrin™ is recombinant human transferrin that is completelyblood-free. Optiferrin’s performance is equivalent to human holo transferrin incell culture and offers significant regulatory advantages due to its safety andconsistency. Optiferrin is suitable for a broad range of cell types thatinclude stem, primary, and bioproduction cells.

Application

Transferrin Human has been used to perform immunoprecipitation measurements. It has also been used for the preparation of essential 8 medium.

Biochem/physiol Actions

Human transferrin was shown to promote allogeneic chimerism in mice after irradiation and transplantation of incompatible bone marrow.
Transferrin facilitates the transfer of iron to erythron and peripheral tissues. It stimulates the proliferation of human lymphocytes. Mutations in this gene are linked to atransferrinemia.

Other Notes

1). Patent Rights
U.S. Patent No. 9,321,828
2). Registered Trademark Rights
U.S. Reg. 3,880,881
International Reg. 1,466,509

Legal Information

Optiferrin is a trademark of InVitria

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis
Tolosano E
The Hematology Journal : The Official Journal of the European Haematology Association / EHA (2015)
E Axelman et al.
Thrombosis and haemostasis, 112(3), 466-477 (2014-07-18)
Heparanase is implicated in cell invasion, tumour metastasis and angiogenesis. It forms a complex and enhances the activity of the blood coagulation initiator - tissue factor (TF). We describe new peptides derived from the solvent accessible surface of TF pathway
A remote-controlled immunochemical system for nephelometric detection of human serum transferrin
Strzelak K and Koncki R
Biosensors And Bioelectronics, 127(2), 31-37 (2019)
Effect of human transferrin on the engraftment of allogeneic bone marrow in various strans of lethally irradiated mice.
Pierpaoli W.
Nature Immunology, 11, 356-365 (1992)
Effect of transferrin, lactoferrin and chelated iron on human T-lymphocytes
Djeha A and Brock JH
British Journal of Haematology, 80(2), 235-241 (1992)
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