T2952

Tetrabenazine

≥98% (HPLC), solid

• Sinónimos: 9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-(rel 3R,11bR)-2H-benzo[a]quinolizin-2-one
• Fórmula empírica (notación de Hill): C₁₉H₂₇NO₃
• Número de CAS: 58-46-8
• Peso molecular: 317.42
• Beilstein/REAXYS Number: 40090
• EC Number: 200-383-6
• MDL number: MFCD08461052
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826731
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: COc1cc2CCN3C[C@@H](CC(C)C)C(=O)CC3c2cc1OC
• InChI: 1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m1/s1
• InChI key: MKJIEFSOBYUXJB-GDBMZVCRSA-N

Descripción

Application

Tetrabenazine has been used for dopamine uptake assays in mouse brain cells¹. Tetrabenazine has also been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells².

Biochem/physiol Actions

Tetrabenazine is a reversible type 2 vesicular monoamine transporter (VMAT) inhibitor. It depletes dopamine stores.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Tetrabenazine is soluble in DMSO at a concentration that is greater than 10 mg/ml and is insoluble in water.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves