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T1892

Sigma-Aldrich

Thioflavine S

Practical grade, powder

Sinónimos:

Direct Yellow 7

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About This Item

Número de CAS:
1326-12-1
Colour Index Number:
49010
EC Number:
215-418-0
MDL number:
MFCD00071453
UNSPSC Code:
12171500
NACRES:
NA.47

Nombre del producto

Thioflavine S, practical grade

grade

practical grade

form

powder

technique(s)

microbe id | staining: suitable

color

light beige to dark beige, to Dark Brown

solubility

ethanol: water (1:1): 1 mg/mL

λmax

360-380

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

S1c2c(ccc(c2)C)N(C1=C3C=CC(=[N+](C)C)C=C3)C.[Cl-]

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

General description

Thioflavine S aids in staining and visualizing β-amyloid plaques in Alzheimer′s disease. Thioflavin S binds to fibrillar β-amyloid plaques, and does not diffuse in the plaques. Thioflavin-S staining aids in visualizing smaller plaques throughout the neocortex, hippocampus and thalamic region.

Application

Thioflavine S has been used to stain and visualize β-amyloid structures in the tissue sections.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
SHBM5906
MKCH4108
MKCC1990
MKBS5728V
MKBS4530V

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Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta
Racke MM, et al.
The Journal of Neuroscience, 25(3), 629-636 (2005)
Disha Shah et al.
PloS one, 8(12), e84241-e84241 (2013-12-21)
Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD is a complex disorder, characterised by several pathological features. The problem with FC studies in patients is that it
Attenuation of beta-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity
Yuan P and Grutzendler J
The Journal of Neuroscience, 36(2), 632-641 (2016)
Genetic modulation of soluble A beta rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease
Fowler SW, et al.
The Journal of Neuroscience, 34(23), 7871-7885 (2014)
Farah H Bardai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(1), 108-119 (2017-11-16)
The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), which is caused by mutations in tau.
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