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Merck
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Key Documents

SRP6543

Sigma-Aldrich

Netrin-1 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinónimos:

NTN1

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

~800 kDa (Human netrin-1 aa 25-604 is fused at the C-terminus to a FLAG0174-tag.)

packaging

pkg of 10 μg

impurities

<0.1 EU/μg endotoxin (LAL test)

UniProt accession no.

O95631

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NTN1(9423)

General description

Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.

Physical form

Lyophilized in PBS with trehalose and Brij 35.

Reconstitution

Reconstitute with 100 μsterile distilled water.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Joo In Park et al.
Journal of Korean medical science, 22(4), 641-645 (2007-08-31)
Netrin is a neuronal guidance molecule implicated in the development of spinal commissural neurons and cortical neurons. The attractive function of netrin requires the receptor, Deleted in Colorectal Cancer (DCC), while the receptor Unc5h is involved in the repulsive action
Tracy S Tran et al.
Neural development, 8, 15-15 (2013-08-02)
Spinal commissural axons represent a model system for deciphering the molecular logic that regulates the guidance of midline-crossing axons in the developing central nervous system (CNS). Whether the same or specific sets of guidance signals control the navigation of molecularly
Valbona Mirakaj et al.
The Journal of experimental medicine, 211(6), 1037-1048 (2014-05-28)
Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression of netrin-1, an axonal guidance molecule that activates resolution, and that vagotomy
Jovana Drinjakovic et al.
Neuron, 65(3), 341-357 (2010-02-18)
Regulated protein degradation via the ubiquitin-proteasome system (UPS) plays a central role in building synaptic connections, yet little is known about either which specific UPS components are involved or UPS targets in neurons. We report that inhibiting the UPS in
Luqi Duan et al.
Toxicological sciences : an official journal of the Society of Toxicology, 175(2), 168-181 (2020-03-25)
Acetaminophen (APAP) overdose-induced acute liver failure is an important clinical problem in the United States and the current antidote N-acetylcysteine, has a short early therapeutic window. Since most patients present late to the clinic, there is need for novel late-acting
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