SRP6370

Aldolase A human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Sinónimos: ALDA, ALDOA, Fructose bisphosphate Aldolase A, GSD12
• UNSPSC Code: 12352204
• NACRES: NA.32

Propiedades

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥95% (SDS-PAGE)
• form: liquid
• mol wt: 41.5 kDa (384 aa, 1-364 aa + His Tag)
• packaging: pkg of 100 μg
• concentration: 1 mg/mL
• UniProt accession no.: P04075
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... ALDOA(226)

Descripción

General description

Aldolase A (ALDOA) is a ubiquitous glycolytic enzyme expressed in developing embryos and in adult muscles. The gene encoding it is localized on human chromosome 16p11.2. Recombinant human Aldolase A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Biochem/physiol Actions

In glycolysis, aldolase A (ALDOA) catalyzes the reversible reaction of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. It is involved in a wide range of cellular functions such as maintenance of striated muscle contraction, cell shape and mobility, actin filament organization and ATP biosynthetic process. High expression level of ALDOA is reported in various forms of malignant cancers, including human lung squamous, renal cell and hepatocellular carcinomas. ALDOA deficiency causes myopathy and hemolytic anemia.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl and 10% glycerol.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable