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Merck
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Key Documents

SRP6323

Sigma-Aldrich

Pentraxin 3 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sinónimos:

PTX3, TNFAIP5, TSG-14

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

liquid

mol wt

44.4 kDa (401 aa, 18-381 aa + His Tag)

packaging

pkg of 100 μg

concentration

1 mg/mL

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

P26022

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PTX3(5806)

General description

Pentraxin 3 (PTX3) or tumor necrosis factor (TNF)-stimulated gene is the prototypic member of the long pentraxin family sharing the C-terminal domain with short pentraxins and containing a unique N-terminal domain. The gene encoding this protein is localized on human chromosome 3q25.32 and consists of 3 exons. Recombinant human Pentraxin 3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Biochem/physiol Actions

Pentraxin 3 (PTX3) is an acute phase protein produced and released at inflammatory sites by diverse cell types including monocytes/macrophages, endothelial cells, vascular smooth muscle cells, fibroblasts, and adipocytes. It plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. PTX3 particularly functions as a soluble pathogen recognition receptor and confers resistance against pathogens. Studies indicate that the protein removes apoptotic cells during immune responses. It associates with complement factor H, which is a complement regulator protein.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 1 mM DTT.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Bongkun Choi et al.
Oncotarget, 5(2), 481-492 (2014-01-25)
Pentraxin 3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity of malignancies, but its exact role remains unclear. This study found that PTX3 expression was up-regulated in distant bone metastases of
Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis.
Hung TW
Cellular Physiology and Biochemistry, 40(5), 1029-1038 (2016)
Simone Bastrup-Birk et al.
PloS one, 8(9), e73119-e73119 (2013-09-17)
The long pentraxin-3 (PTX3) is a key component of the humoral arm of the innate immune system. PTX3 is produced locally in response to pro-inflammatory stimuli. To investigate PTX3 levels and its use as a biomarker in patients with systemic
Pentraxin-3 and the right ventricle: the Multi-Ethnic Study of Atherosclerosis?Right Ventricle Study
Peter Leary
Pulmonary Circulation, 4.2 (2014)
Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells
Narae Hwang
Korean Journal of Ophthalmology : KJO, 30(6), 468-478 (2016)
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