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SRP3328

Sigma-Aldrich

IL-9 human

Animal-component free, ≥98% (SDS-PAGE & HPLC), recombinant, expressed in E. coli, lyophilized

Sinónimos:

T-cell growth factor p40, p40 cytokine

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

Nombre del producto

IL-9 human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

potency

≤0.2 ng/mL ED50

mol wt

14.0 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

UniProt accession no.

P15248

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL9(3578)

General description

IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin′s disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant human IL-9 is a 14.0 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human and murine proteins.

Biochem/physiol Actions

IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. Recombinant human IL-9 is a 14.0 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human and murine proteins.

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Fitzgerald, K.A. et al.
The Cytokine Handbook, 85-89 (2001)
K Kelleher et al.
Blood, 77(7), 1436-1441 (1991-04-01)
We have isolated the genomic sequence of human interleukin-9 (IL-9) based on its sequence homology with a human IL-9 cDNA isolated from human T-cell leukemia virus (HTLV)-I-transformed T cells by expression cloning. The entire genomic sequence has been determined and
Gabriella Ruocco et al.
Clinical science (London, England : 1979), 129(4), 291-303 (2015-02-24)
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by persistent inflammation orchestrated by cluster of differentiation (CD) 4 T helper (Th) cells. In particular, Th1 and Th17 cells amplify, whereas T regulatory (Treg) cells
Juan Liu et al.
The Journal of investigative dermatology, 134(7), 1903-1911 (2014-02-04)
The cytokine IL-9, derived primarily from T-helper 9 (Th9) lymphocytes, promotes expansion of the Th2 subset and is implicated in the mechanisms of allergic asthma. We hypothesize that IL-9 also has a role in human allergic contact dermatitis (ACD). To

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