Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

SML3240

Sigma-Aldrich

CL264

≥98% (HPLC)

Sinónimos:

2-(4-((6-Amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzamido)acetic acid, CL 264, CL-264, N-[4-[[6-Amino-2-(butylamino)-7,8-dihydro-8-oxo-9H-purin-9-yl]methyl]benzoyl]glycine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C19H23N7O4
Número de CAS:
1510712-69-2
Peso molecular:
413.43
MDL number:
MFCD32671317
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

General description

CL264 is a hydrophilic molecule. CL264,an adenine analog, is a potent and selective toll-like receptor 7 (TLR7) agonist with no TLR8-stimulating potency. This bioactive small molecule belongs to the category of 9-benzyl-8-hydroxyadenine derivatives. It contains a glycine molecule attached to the benzyl group. Studies show that CL264 is capable of activating NF-κB and stimulating the secretion of IFN-α in cells that express TLR7. CL264 is commonly used at a concentration range from 2 ng/mL to 10 μg/mL for stimulating cells in cultures.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Joseph Skurski et al.
Frontiers in cellular and infection microbiology, 10, 620392-620392 (2021-02-16)
A well-controlled innate immune response is characterized by a rapid yet self-limiting inflammatory response. Although much is known about the range of inflammatory stimuli capable of triggering an innate immune response, the mechanisms which govern the degree of inflammation induced
Jahnavi Aluri et al.
Blood, 137(18), 2450-2462 (2021-01-30)
Inborn errors of immunity (IEI) are a genetically heterogeneous group of disorders with a broad clinical spectrum. Identification of molecular and functional bases of these disorders is important for diagnosis, treatment, and an understanding of the human immune response. We
Kamil Krawczynski et al.
Journal of cell science, 134(5) (2020-10-24)
The function of microRNAs (miRNAs) can be cell autonomous or communicated to other cell types and has been implicated in diverse biological processes. We previously demonstrated that miR-517a-3p (miR-517a), a highly expressed member of the chromosome 19 miRNA cluster (C19MC)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico