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Merck

SML2025

Sigma-Aldrich

AH-7614

≥98% (HPLC)

Sinónimos:

4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide, AH 7614, Compound 39, NSC 31171, p-Toluenesulfonamide, N-xanthen-9-yl-

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About This Item

Fórmula empírica (notación de Hill):
C20H17NO3S
Número de CAS:
Peso molecular:
351.42
MDL number:
UNSPSC Code:
41121800
NACRES:
NA.77

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(NC1C2=C(C=CC=C2)OC3=C1C=CC=C3)(C4=CC=C(C)C=C4)=O

InChI

1S/C20H17NO3S/c1-14-10-12-15(13-11-14)25(22,23)21-20-16-6-2-4-8-18(16)24-19-9-5-3-7-17(19)20/h2-13,20-21H,1H3

InChI key

OZCQEUZTOAAWDK-UHFFFAOYSA-N

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1 of 4

Este artículo
SML2950SML0526SML1323
AH-7614 ≥98% (HPLC)

SML2025

AH-7614

E7820 ≥98% (HPLC)

SML2950

E7820

EHop-016 ≥98% (HPLC)

SML0526

EHop-016

NU6140 ≥98% (HPLC)

SML1323

NU6140

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

AH-7614 is a potent negative allosteric modulator (NAM) of the long-chain free fatty acid receptor FFA4 that prevents differentiation of a mouse mesenchymal stem cell line toward an adipocyte phenotype. AH-7614 (Compound 39) was first described as antagonist of FFA4 that blocks activation of FFA4 by polyunsaturated, ω-6 fatty acid, linoleic acid and GSK137647A.
Potent negative allosteric modulator (NAM) of the long-chain free fatty acid receptor FFA4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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    S Villegas-Comonfort et al.
    Prostaglandins, leukotrienes, and essential fatty acids, 117, 1-10 (2017-02-27)
    Arachidonic acid increased intracellular calcium, in cells expressing green fluorescent protein-tagged human FFA4 receptors, with an EC
    Kenneth R Watterson et al.
    Molecular pharmacology, 91(6), 630-641 (2017-04-08)
    High-affinity and selective antagonists that are able to block the actions of both endogenous and synthetic agonists of G protein-coupled receptors are integral to analysis of receptor function and to support suggestions of therapeutic potential. Although there is great interest
    Steven M Sparks et al.
    Bioorganic & medicinal chemistry letters, 24(14), 3100-3103 (2014-06-03)
    The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8

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