SML1626

TFCA

≥98% (HPLC)

• Sinónimos: 3-(3,4-Dimethoxyphenyl)-N-[4-(trifluoromethyl)phenyl]-2-propenamide, N-(4-Trifluoromethylphenyl) 3,4-dimethoxycinnamamide
• Fórmula empírica (notación de Hill): C₁₈H₁₆F₃NO₃
• Número de CAS: 895700-18-2
• Peso molecular: 351.32
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825510
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: room temp
• SMILES string: O=C(NC1=CC=C(C(F)(F)F)C=C1)/C=C/C2=CC=C(OC)C(OC)=C2
• InChI: 1S/C18H16F3NO3/c1-24-15-9-3-12(11-16(15)25-2)4-10-17(23)22-14-7-5-13(6-8-14)18(19,20)21/h3-11H,1-2H3,(H,22,23)/b10-4+
• InChI key: KFWWXJZNIMFFRO-ONNFQVAWSA-N

Descripción

Biochem/physiol Actions

TFCA is a Liver X receptor α (LXRα) antagonist that reduces lipid accumulation and fatty liver in mice. Apparently TFCA binds to the LXR? ligand binding domain and induces interaction with NCoR corepressor.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable