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Merck

SML1555

Sigma-Aldrich

MS023 hydrochloride

≥98% (HPLC)

Sinónimos:

N1-((4-(4-Isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine hydrochloride, N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C17H25N3O · xHCl
Número de CAS:
Peso molecular:
287.40 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

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Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

CN(CCN)CC1=CNC=C1C2=CC=C(OC(C)C)C=C2.[H]Cl

InChI

1S/C17H25N3O.ClH/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18;/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3;1H

InChI key

IEZPALXFXHDDHI-UHFFFAOYSA-N

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1 of 4

Este artículo
SML1225SML2371SML1276
Indisulam ≥98% (HPLC)

SML1225

Indisulam

BAZ2-ICR ≥98% (HPLC)

SML1276

BAZ2-ICR

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

-

solubility

H2O: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

Biochem/physiol Actions

MS023 is a potent and selective chemical probe for Type I protein arginine methyltransferases (PRMTs). MS023 is a potent inihbitor of PRMTs 1,3,4,6,and 8 (IC50 = 30, 119, 83, 8, and 8 nM, respectively), which are responsible for asymmetric dimethylation of arginine residues. MS023 is active in cells. For full characterization details, please visit the MS023 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

MS023 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

MS023 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the MS023 probe summary on the Chemical Probes Portal website.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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    Biomolecular condensation is a widespread mechanism of cellular compartmentalization. Because the "survival of motor neuron protein" (SMN) is implicated in the formation of three different membraneless organelles (MLOs), we hypothesized that SMN promotes condensation. Unexpectedly, we found that SMN's globular

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