SML1385

Lomitapide

≥98% (HPLC)

• Sinónimos: AEGR-733, BMS-201038, N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]2-yl]carbonyl]amino]-1-piperidinyl]butyl]9H-fluoren-9-carboxamde
• Fórmula empírica (notación de Hill): C₃₉H₃₇F₆N₃O₂
• Número de CAS: 182431-12-5
• Peso molecular: 693.72
• Número MDL: MFCD16620494
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 329825833
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 20 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(NCC(F)(F)F)C1(C(C=CC=C2)=C2C3=C1C=CC=C3)CCCCN(CC4)CCC4NC(C5=C(C6=CC=C(C(F)(F)F)C=C6)C=CC=C5)=O
• InChI: 1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
• Clave InChI: MBBCVAKAJPKAKM-UHFFFAOYSA-N
• Información sobre el gen: human ... MTTP(4547) , P4HB(5034)

Descripción

Aplicación

Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.

Acciones bioquímicas o fisiológicas

Lomitapide can lower the secretion of very-low-density lipoproteins (VLDL) and chylomicrons.

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable