Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

Otros documentos

SML1044

Sigma-Aldrich

Zosuquidar hydrochloride

≥98% (HPLC), powder, p-Glycoprotein inhibitor

Sinónimos:

(2R)-Anti-5-[3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy]quinoline hydrochloride, LY-335979, RS-33295-198

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C32H31F2N3O2 · xHCl
Número de CAS:
167354-41-8
Peso molecular:
527.60 (free base basis)
UNSPSC Code:
12161501
PubChem Substance ID:
329825638
NACRES:
NA.77

product name

Zosuquidar hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 4 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

O[C@@H](COC1=C(C=CC=N2)C2=CC=C1)CN(CC3)CCN3[C@@H]4C5=C(C=CC=C5)[C@@H]6[C@@H](C6(F)F)C7=C4C=CC=C7.Cl

InChI

1S/C32H31F2N3O2.ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;/h1-14,21,29-31,38H,15-20H2;1H/t21-,29-,30+,31-;/m1./s1

InChI key

VQJFFWJUYDGTQZ-FCNWNIDBSA-N

Biochem/physiol Actions

Zosuqidar is a potent inhibitor of P-glycoprotein (P-gp, MDR1) a transporter protein that is a key modulator of cellular drug efflux. Zosuquidar sensitizes AML, and other cancer cell lines to cytotoxic drugs.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Yoko Nagaya et al.
Drug metabolism and disposition: the biological fate of chemicals, 48(11), 1183-1190 (2020-08-31)
Estimation of unbound drug concentration in the brain (Cu,brain) is an essential part of central nervous system (CNS) drug development. As a surrogate for Cu,brain in humans and nonhuman primates, drug concentration in cerebrospinal fluid (CCSF) collected by lumbar puncture
J Vérité et al.
Journal of neuroinflammation, 15(1), 182-182 (2018-06-15)
Alzheimer's disease is widely described since the discovery of histopathological lesions in Mrs. Auguste Deter in 1906. However to date, there is no effective treatment to deal with the many cellular and molecular alterations. The complexity is even higher with
Kamil Nosol et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(42), 26245-26253 (2020-10-07)
ABCB1 detoxifies cells by exporting diverse xenobiotic compounds, thereby limiting drug disposition and contributing to multidrug resistance in cancer cells. Multiple small-molecule inhibitors and inhibitory antibodies have been developed for therapeutic applications, but the structural basis of their activity is

Contenido relacionado

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico