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SML0400

Sigma-Aldrich

ML204

≥98% (HPLC)

Sinónimos:

4-Methyl-2-(1-piperidinyl)-quinoline

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About This Item

Fórmula empírica (notación de Hill):
C15H18N2
Número de CAS:
5465-86-1
Peso molecular:
226.32
MDL number:
MFCD00817920
UNSPSC Code:
12352200
PubChem Substance ID:
329825396
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL at warmed (clear solution)

storage temp.

2-8°C

SMILES string

Cc1cc(nc2ccccc12)N3CCCCC3

InChI

1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3

InChI key

USYRQXDHKXGTCK-UHFFFAOYSA-N

Application

4-methyl-2-(1- piperidinyl)-quinoline (ML204) has been used to attenuate Ewing sarcoma (EWS)-FLI1 activity in TC32 cells. It has also been used to attenuate scratching behavior evoked by α-Me-5HT in mice.

Biochem/physiol Actions

ML204 is a potent and selective TRPC4 channel inhibitor.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
035M4607V
054M4609V
062M4621V

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Peng Sun et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 34(12), 2164-2172 (2017-09-25)
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Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice
Lee SH, et al.
The Journal of Allergy and Clinical Immunology, 142(4), 1349-1352 (2018)
Stephanie D Jones et al.
Zoology (Jena, Germany), 118(6), 439-445 (2015-08-25)
The phenotype-linked fertility hypothesis proposes that secondary sexual characters (SSCs) advertise a male's fertility to prospective mates. However, findings from empirical studies attempting to test this hypothesis are often ambivalent or even contradictory, and few studies have simultaneously evaluated how
Domingos M S Pereira et al.
Oxidative medicine and cellular longevity, 2018, 4904696-4904696 (2018-07-10)
Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions in the host are less well understood. Reduced human Trx activates transient receptor potential canonical 5 (TRPC5) in inflammation, but there is no evidence of
Englerin A inhibits EWS-FLI1 DNA binding in Ewing sarcoma cells
Caropreso V, et al.
The Journal of Biological Chemistry, 291(19), 10058-10066 (2016)
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