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SML0246

Sigma-Aldrich

Tirofiban hydrochloride monohydrate

≥98% (HPLC)

Sinónimos:

L 700462, MK 383, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine

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About This Item

Fórmula empírica (notación de Hill):
C22H36N2O5S·HCl·H2O
Número de CAS:
150915-40-5
Peso molecular:
495.07
MDL number:
MFCD07368623
UNSPSC Code:
12352200
PubChem Substance ID:
329825256
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -10 to -18° (c=1, MeOH)

storage condition

desiccated

color

white to beige

solubility

DMSO: >12 mg/mL at warmed to 60 °C

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC([C@@H](NS(CCCC)(=O)=O)CC1=CC=C(C=C1)OCCCCC2CCNCC2)=O.Cl.O

InChI

1S/C22H36N2O5S.ClH.H2O/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18;;/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26);1H;1H2/t21-;;/m0../s1

InChI key

HWAAPJPFZPHHBC-FGJQBABTSA-N

Gene Information

human ... ITGA2B(3674) , ITGB3(3690)

Application

Tirofiban hydrochloride monohydrate has been used as an αIIbβ3 integrin (glycoprotein IIb/IIIa) inhibitor for mouse induced pluripotent stem cell (iPSC) culture.

Biochem/physiol Actions

Tirofiban hydrochloride is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. Blocks platelet aggregation and thrombus formation.
Tirofiban might cause thrombocytopenia.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Yu-Lun Tseng et al.
Toxicology and applied pharmacology, 364, 106-113 (2018-12-29)
Collagen and convulxin induce platelet aggregation through glycoprotein VI (GPVI)-FcRγ-Syk signaling pathway. In addition, fibrinogen induces platelet activation through integrin αIIbβ3-FcγRIIa-Syk signaling pathway. We previously reported that high concentrations of selective serotonin reuptake inhibitors (SSRI) reduce platelet aggregation induced by
Xia Hong et al.
Journal of clinical laboratory analysis, 30(2), 108-113 (2014-11-27)
Activated clotting time (ACT) has been successfully applied during percutaneous coronary intervention (PCI) to monitor the extent of thrombin inhibition and anti-coagulation from unfractionated heparin (UFH) aiming to reduce the incidence of thrombotic adverse events and hemorrhagic complications. And this
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)
Inhibition of the integrin signal constitutes a mouse iPS cell niche.
Higuchi S, et al.
Development, Growth & Differentiation, 58(7), 586-599 (2016)
C J Panebianco et al.
European cells & materials, 39, 211-226 (2020-05-13)
Back pain is a leading cause of global disability associated with intervertebral disc (IVD) pathologies. Discectomy alleviates disabling pain caused by IVD herniation without repairing annulus fibrosus (AF) defects, which can cause accelerated degeneration and recurrent pain. Biological therapies show
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