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Key Documents

SCP0153

Sigma-Aldrich

GLP-1 (Preproglucagon 72-107 amide) (GLP-1 human)

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About This Item

Fórmula empírica (notación de Hill):
C184H273N51O57
Peso molecular:
4111.44
UNSPSC Code:
12352200
NACRES:
NA.32

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥75%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Application

GLP-1 (Preproglucagon 72-107 amide) (GLP-1 human) has been used to study its effect on vascular endothelial growth factor-A (VEGFA)-mediated endothelium-dependent signaling and vasodilation.
Glycogen-like peptide-1 (GLP-1) is an amino acid peptide derived from proglucogon. GLP-1 is involved in the regulation of the glycemic index via its affect on glucagon and insulin levels. GLP-1 may be used to study its interaction with its receptor, the GLP-1 receptor.

Biochem/physiol Actions

Glycogen-like peptide-1 (GLP-1) is an insulinotropic hormone, which takes part in increasing insulin secretion and insulin sensitivity. It also inhibits the secretion of glycogen and reduces fasting glucose levels.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries
Egholm C, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 311(5), H1214-H1224 (2016)
Voglibose: an alpha-glucosidase inhibitor
Dabhi AS, et al.
Journal of Clinical and Diagnostic Research : JCDR, 7(12), 3023-3023 (2013)
Alaa Al Helaili et al.
Biochemical and biophysical research communications, 533(1), 110-117 (2020-09-19)
Dysfunction of the gut-brain axis is one of the potential contributors to the pathophysiology of obesity and is therefore a potential target for treatment. Vagal afferents innervating the gut play an important role in controlling energy homeostasis. There is an
Cecilie Egholm et al.
American journal of physiology. Heart and circulatory physiology, 311(5), H1214-H1224 (2016-11-03)
We investigated the acute effects of glucagon-like peptide-1 (GLP-1), GLP-1(1-36), and GLP-1(7-36) on vascular endothelial growth factor-A (VEGFA)-induced endothelium-dependent signaling and vasodilation. Our hypothesis was that GLP-1 released from intestinal l-cells modulates processes related to PLCγ activation, Src, and endothelial

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