SAB5702142

Anti-Proteinase 3/PR3 Antibody, clone 3I3M1, Rabbit Monoclonal

• Sinónimos: ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3
• UNSPSC Code: 12352203
• NACRES: NA.46

Propiedades

• biological source: rabbit
• Quality Level: 100
• material: colorless
• clone: 3I3M1, monoclonal
• form: liquid
• mol wt: 28 kDa
• species reactivity: mouse, mouse
• concentration: 0.39 mg/mL
• technique(s): immunofluorescence: 1:50 - 1:200; western blot: 1:500 - 1:2000
• color: colorless
• isotype: IgG
• immunogen sequence: MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHF
• UniProt accession no.: P24158
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PRTN3(5657)

Descripción

General description

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro. By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Proteinase 3/PR3 (P24158).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB, IF/ICC

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1