SAB5600038

Anti-Gamma H2AX (phospho-Ser139) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM224, purified immunoglobulin

• Sinónimos: H2AX Ser139 p, Histone H2AX (phospho ser139)
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• recombinant: expressed in HEK 293 cells
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: RM224, monoclonal; recombinant monoclonal
• form: buffered aqueous glycerol solution
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): ELISA: 0.2- 1 μg/mL; immunoblotting: 0.5-2 μg/mL; immunocytochemistry: 0.5-2 μg/mL
• isotype: IgG
• NCBI accession no.: 3014
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer139)
• Gene Information: human ... H2AX(3014)

Descripción

General description

Histone H2AX (H2A histone family member X), a histone variant present in almost all eukaryotes, is coded by H2AFX gene. It is mapped to human chromosome 11q23.2–11q23.3.

Specificity

This antibody reacts to Histone H2A.X only when phosphorylated at serine 139. No cross reactivity with other phosphorylated histones.

Immunogen

Synthetic peptide corresponding to Phospho-Histone H2AX (Ser139)

Biochem/physiol Actions

H2AX (H2A histone family member X) helps to maintain genome stability. It plays an important role in localisation and structuring of the repair focus. H2AX also plays an active role in supplying the active repair proteins. γH2AX participates in DSB repair. This protein serves as a signal and target of phosphorylation in the spreading phase.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable