SAB4504254

Anti-phospho-Kv1.3/KCNA3 (pTyr¹³⁵) antibody produced in rabbit

affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 58 kDa
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P22001
• UniProt accession no.: P22001
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr135)
• Gene Information: human ... KCNA3(3738)

Descripción

General description

The voltage-dependent potassium channel (Kv1.3/KCNA3) is expressed in the nervous and immune systems. This gene is located on human chromosome 1p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Kv1.3/KCNA3 around the phosphorylation site of Tyr135.

Immunogen Range: 101-150

Biochem/physiol Actions

The voltage-dependent potassium channel (Kv1.3/KCNA3) plays a major role in setting the resting membrane potential, cell proliferation, apoptosis and volume regulation. This protein participates in immunomodulation of autoreactive effector and memory T cell-mediated autoimmune diseases. KCNA3 is required for T-cell proliferation and activation.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable