SAB4501406

Anti-Nuclear Receptor NR4A1 antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Early response protein NAK1, Nuclear receptor subfamily 4 group A member 1, Orphan nuclear receptor HMR, ST-59, TR3 orphan receptor
• UNSPSC Code: 12352203
• NACRES: NA.41
• conjugate: unconjugated
• application: ELISA; IHC; WB
• clone: polyclonal
• species reactivity: rat, human, mouse
• citations: 5
• technique(s): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 64 kDa
• species reactivity: rat, human, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P22736
• UniProt accession no.: P22736
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NR4A1(3164)

Descripción

General description

Nuclear receptor subfamily 4 group A member1 (NR4A1) is an orphan receptor that belongs to the nuclear hormone receptor superfamily. The NR4A1 gene is mapped to human chromosome 12q13.13. Structurally, NR4A1 comprises an N-terminal AB region, DNA binding domain (DBD), and a C-terminal ligand-binding domain (LBD). Anti-Nuclear Receptor NR4A1 antibody detects endogenous levels of total Nuclear Receptor NR4A1 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Nuclear Receptor NR4A1.

Immunogen Range: 317-366

Biochem/physiol Actions

Nuclear receptor subfamily 4 group A member1 (NR4A1) participates in gene expression regulation in the hypothalamic-pituitary-adrenal axis (HPA) especially those related to inflammation and steroidogenesis. The levels of NR4A1 are downregulated in metastatic melanoma, myelogenous leukemia, and follicular thyroid carcinoma. An elevated expression of NR4A1 is observed in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in mouse models. Dysfunction of NR4A1 is correlated to energy balance and also the events of metabolic pathways including carbohydrates and lipids. NR4A1 contributes to arterial vessel cell wall damage. It regulates tumor cell proliferation, migration, and invasion. NR4A1 may serve as a biomarker for depression and other psychiatric disorders.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable