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SAB4500889

Sigma-Aldrich

Anti-FGFR2 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

BEK, BFR-1, ECT1, FGFR-2, Fibroblast growth factor receptor 2 precursor

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About This Item

MDL number:
MFCD02096345
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 92 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P21802

UniProt accession no.

P21802

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FGFR2(2263)

General description

Anti-FGFR2 Antibody detects endogenous levels of total FGFR2 protein.

Fibroblast growth factor receptor 2 (FGFR2), a membrane-spanning tyrosine kinase belongs to the fibroblast growth factor (FGF) family. It is expressed in epithelium, developing central nervous system and in bone rudiments. It is located on human chromosome 10q26.

Immunogen

The antiserum was produced against synthesized peptide derived from human FGFR2.

Immunogen Range: 471-520

Biochem/physiol Actions

Fibroblast growth factor receptor 2 (FGFR2) mutations show poor clinical diagnosis in endometrioid endometrial cancer. The FGFR2 gene participates in directional epithelial-mesenchymal signaling in the endometrium. It is essential for placentation and limb induction.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
Pollock PM, et al.
Oncogene, 26, 7158-7162 (2007)
The imprinted gene and parent-of-origin effect database now includes parental origin of de novo mutations
Glaser RL, et al.
Nucleic Acids Research (2006)
FGFR2 mutations are associated with poor outcomes in endometrioid endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study.
Jeske YW
Gynecologic Oncology, 145, 366-366 (2017)
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
Xu X, et al.
Development, 125, 753-765 (1998)
Masako Yokota et al.
PloS one, 9(7), e101693-e101693 (2014-07-09)
Apert syndrome is an autosomal dominantly inherited disorder caused by missense mutations in fibroblast growth factor receptor 2 (FGFR2). Surgical procedures are frequently required to reduce morphological and functional defects in patients with Apert syndrome; therefore, the development of noninvasive

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