SAB4200575

Anti-SLC40A1 antibody produced in rabbit

IgG fraction of antiserum

• Sinónimos: Ferroportin-1(FPN1), HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3, solute carrier family 40 (iron-regulated transporter) member 1,
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• form: buffered aqueous solution
• mol wt: ~60 kDa
• species reactivity: rat, human
• technique(s): immunoblotting: 1:1,000-1:2,000 using rat kidney extracts (S1 fraction); immunohistochemistry: 1:50-1:100 using formalin-fixed paraffin-embedded human duodenum
• UniProt accession no.: Q9NP59
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SLC40A1(30061) ; rat ... Slc40a1(170840)

Descripción

General description

SLC40A1 (also known as ferroportin, FPN1), also called iron-regulated transporter 1 (IREG1), is an iron transporter expressed in liver, duodenum and kidney. SLC40A1 is also expressed in the brain, duodenal mucosa, in neuronal cells and endothelial cells of the blood-brain barrier.

Immunogen

synthetic peptide corresponding to an internal sequence of human SLC40A1, conjugated to KLH.

Application

Anti-SLC40A1 antibody produced in rabbit has been used in western blotting and immunohistochemistry.

Biochem/physiol Actions

Ferroportin 1(FPN1) plays a central role in systemic iron homeostasis and is critical for normal intestinal iron absorption. SLC40A1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Hepcidin binds to and inhibits solute carrier family FPN1, thus preventing enterocytes of the intestines from secreting iron into the hepatic portal system, thereby functionally reducing iron absorption. Ferroportin in neuronal cells is required for cellular Fe²⁺ export, a process critical for normal neuronal function. It has been shown to interact with amyloid precursor protein (APP), to facilitate the iron export process from neuronal cells. Mutations in the FPN1 gene have been linked to hereditary hemochromatosis, a common disorder characterized by iron overload and multi-organ damage.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable