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Key Documents

SAB2501381

Sigma-Aldrich

Anti-Cd28 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-CH29-189K17.3, Anti-OTTMUSP00000002157, CD28 antigen, T-cell-specific surface glycoprotein CD28

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, pig

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cd28(12487)

General description

Cluster of differentiation 28 (CD28) antigen is a co-stimulatory receptor expressed in naive T-cells. It contains a short cytoplasmic tail and two proline-rich motifs.

Immunogen

Peptide with sequence KEKHLCHTQSSPK, from the internal region of the protein sequence according to NP_031668.3

Biochem/physiol Actions

Cluster of differentiation 28 (CD28) antigen has a role in T-cell activation, proliferation, survival and function. It modulates thymic development, peripheral homeostasis and the suppressive functions of regulatory T cells. CD28 has a role in signal transduction and is involved in activating many adaptor proteins.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Defects in regulatory T cells due to CD28 deficiency induce a qualitative change of allogeneic immune response in chronic graft-versus-host disease.
Akieda Y
Journal of Immunology (2015)
Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.
Frohlich M
European Journal of Immunology (2016)
CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells.
Macal M
Journal of Immunology (2016)
CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif.
Rozanski CH
Journal of Immunology (2015)
Nicole A Braun et al.
American journal of respiratory and critical care medicine, 190(5), 560-571 (2014-07-30)
Effective therapeutic interventions for chronic, idiopathic lung diseases remain elusive. Normalized T-cell function is an important contributor to spontaneous resolution of pulmonary sarcoidosis. Up-regulation of inhibitor receptors, such as programmed death-1 (PD-1) and its ligand, PD-L1, are important inhibitors of

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