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Key Documents

SAB1403211

Sigma-Aldrich

Monoclonal Anti-MYLIP antibody produced in mouse

clone 3C10, purified immunoglobulin, buffered aqueous solution

Sinónimos:

MIR

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3C10, monoclonal

form

buffered aqueous solution

mol wt

antigen ~75.06 kDa

species reactivity

human

technique(s)

capture ELISA: suitable
indirect ELISA: suitable

isotype

IgG2aκ

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYLIP(29116)

General description

Mouse monoclonal antibody raised against a full-length recombinant MYLIP.
Myosin regulatory light chain interacting protein (MYLIP) is an E3 ubiquitin ligase. The gene encoding it is localized on human chromosome 6p22.3.

Immunogen

MYLIP (AAH02860, 1 a.a. ~ 445 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

Biochem/physiol Actions

Myosin regulatory light chain interacting protein (MYLIP) might have a role in cholesterol uptake. It modulates the levels of low density lipoprotein receptor by controlling the ubiquitination of the intracellular tail of the receptor and its lysosomal degradation. Overexpression of the protein in mice livers has been shown to cause hypercholesterolemia and atherosclerosis.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol
Katrina Mitchel
Circulation. Cardiovascular Genetics, 9(3), 223-230 (2016)
Association of MYLIP rs3757354 SNP and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations
Ting-Ting Yan
Lipids in Health and Disease, 11, 141-141 (2012)
IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population
Ashish Dhyani
PLoS ONE, 10(4), e0122414-e0122414 (2015)
Jie Luo et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 5044-5055 (2014-10-08)
Myasthenia gravis (MG) and experimental autoimmune myasthenia gravis (EAMG) are caused by Ab-mediated autoimmune responses to muscle nicotinic acetylcholine receptors (AChRs) that impair neuromuscular transmission, thereby causing muscle weakness. Previously, we discovered that i.p. injection of a therapeutic vaccine consisting

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