S9311

SIB 1893

>99%, solid

• Sinónimos: [E]-2-Methyl-6-[2-phenylethenyl]pyridine
• Fórmula empírica (notación de Hill): C₁₄H₁₃N
• Número de CAS: 7370-21-0
• Peso molecular: 195.26
• MDL number: MFCD02262120
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278718
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: >99%
• form: solid
• solubility: DMSO: 18 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1cccc(\C=C\c2ccccc2)n1
• InChI: 1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
• InChI key: SISOFUCTXZKSOQ-ZHACJKMWSA-N
• Gene Information: human ... GRM1(2911) , GRM5(2915)

Descripción

Application

SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.

Biochem/physiol Actions

SIB 1893 non-competitively inhibits glutamate-induced increase in Ca²⁺ at human metabotropic glutamate receptor 1 (hmGluR1).¹ It also acts as a positive allosteric modulator of hmGluR4.²

Selective and noncompetitive mGlu₅ metabotropic glutamate receptor antagonist.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves