Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

Ver Toda la documentación

S7448

Sigma-Aldrich

STF-62247

≥98% (HPLC), solid

Sinónimos:

N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C15H13N3S
Número de CAS:
315702-99-9
Peso molecular:
267.35
MDL number:
MFCD01121974
UNSPSC Code:
12352200
PubChem Substance ID:
329824583
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 26 mg/mL
H2O: insoluble

storage temp.

room temp

SMILES string

Cc1cccc(Nc2nc(cs2)-c3ccncc3)c1

InChI

1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)

InChI key

KATNUHQNJGNLPW-UHFFFAOYSA-N

Application

STF-62247 may be used as positive control in autophagy inducing cell signaling studies.

Biochem/physiol Actions

STF-62247 induces the formation of large vacuoles in the von Hippel-Lindau deficient renal carcinoma cells, a characteristic of autophagy.1
STF-62247 is a selective inducer of autophagy in VHL-deficient renal cell carcinoma cells.

hcodes

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
032M4745V
030M4741
108K4708

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Sandra Turcotte et al.
Autophagy, 4(7), 944-946 (2008-09-05)
Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor suppressor gene von Hippel-Lindau (VHL). We exploited the possibility of targeting VHL-deficient RCC
Tomohiro Kozako et al.
BMC cancer, 18(1), 791-791 (2018-08-08)
Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of SIRT2 using siRNA causes apoptosis
Kanchan Phadwal et al.
Autophagy, 8(4), 677-689 (2012-02-04)
Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical
Maximilian N Kinzler et al.
Scientific reports, 10(1), 687-687 (2020-01-22)
Induction of autophagy can have beneficial effects in several human diseases, e.g. cancer and neurodegenerative diseases (ND). Here, we therefore evaluated the potential of two novel autophagy-inducing compounds, i.e. STF-62247 and pimozide, to stimulate autophagy as well as autophagic cell
Nadia Bouhamdani et al.
American journal of physiology. Cell physiology, 316(5), C605-C620 (2019-02-14)
Autophagy is a highly conserved, homeostatic process by which cytosolic components reach lysosomes for degradation. The roles played by different autophagic processes in cancer are complex and remain cancer type and stage dependent. Renal cell carcinoma (RCC) is the most
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico