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S7010

Sigma-Aldrich

Span® 60

Sinónimos:

Sorbitan stearate, Sorbitane monostearate

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About This Item

Número de CAS:
1338-41-6
EC Number:
215-664-9
MDL number:
MFCD00005366
UNSPSC Code:
12161900
PubChem Substance ID:
24899728
NACRES:
NA.25

description

non-ionic

Quality Level

200

mol wt

430.63 g/mol

concentration

45-55% (GC)

SMILES string

CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3/t20-,21?,23+,24+/m0/s1

InChI key

HVUMOYIDDBPOLL-XGKPLOKHSA-N

Categorías relacionadas

General description

Span® 60 is a sorbitan monoester than is used as a non-ionic detergent.

Application

Span® 60 has been used in a study to assess encapsulation of doxorubicin in niosomes as a route to tumor targeting. It has also been used in a study to investigate the use of nonionic surfactants as contrast agents for use in diagnostic ultrasounds.

Other Notes

Fatty acid composition: Stearic acid (C18:0) approx. 50%; balance primarily palmitic acid (C16:0).

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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I F Uchegbu et al.
Pharmaceutical research, 12(7), 1019-1024 (1995-07-01)
Encapsulation of doxorubicin in niosomes was sought as a route to tumour targeting and improved tumoricidal through the alteration of doxorubicin pharmacokinetics and metabolism. Doxorubicin niosomes (10 mg kg-1 doxorubicin) prepared from sorbitan monostearate (Span 60), cholesterol and choleth-24 (a
Preparation and properties of vesicles (niosomes) of sorbitan monoesters ([TM="Span"] 20, 40, 60 and 80) and a sorbitan triester ([TM="Span"] 85).
Yoshioka, T., et al.
International Journal of Pharmaceutics, 105, 1-1 (1994)
Surfactant-stabilized microbubbles as ultrasound contrast agents: stability study of [TM="Span"] 60 and Tween 80 mixtures using a Langmuir trough
Singhal, S., et al.
Langmuir, 9, 2426-2426 (1993)
Karimunnisa Sameer Shaikh et al.
Drug development and industrial pharmacy, 36(8), 946-953 (2010-03-04)
Niosomal delivery can prove an alternative to improve the poor skin penetration and residence of the topical antifungal drugs that account for the long treatment regimes in cutaneous mycosis. To investigate niosomes as carriers for dermal delivery of ciclopirox olamine
A Manosroi et al.
International journal of pharmaceutics, 356(1-2), 291-299 (2008-02-19)
Characteristics and physical stability of luciferase plasmid (pLuc) entrapped in cationic bilayer vesicles prepared from various molar ratios of amphiphiles (DPPC, Tween61 or Span60), cholesterol (Chol) and cationic charge lipid (DDAB) were investigated. The cationic liposomes were composed of DPPC/Chol/DDAB
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