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Merck
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Key Documents

P3111

Sigma-Aldrich

Protease from Bacillus sp.

liquid, ≥16 U/g

Sinónimos:

Savinase® 16.0L

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About This Item

EC Number:
232-752-2
MDL number:
MFCD00132092
UNSPSC Code:
12352204
NACRES:
NA.54

biological source

Bacillus sp.

Quality Level

200

form

liquid

specific activity

≥16 U/g

mol wt

20-30 kDa

storage temp.

2-8°C

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Application

Protease is an enzyme used to break down proteins by hydrolyzing peptide bonds. Product P3111 is secreted from Bacillus sp.. It is a serine-type protease characterized by excellent performance at elevated temperature and pH. Product P3111 is extremely stable under harsh storage conditions, such as in the presence of sodium hypochlorite. Protease is used to degrade proteins, to study protease inhibitors and to study thermal inactivation kinetics.

Biochem/physiol Actions

Protease catabolizes proteins by hydrolysis of peptide bonds. Proteases are inactivated by serine active-site inhibitors, such as phenylmethylsulfonyl fluoride (PMSF) and diisopropylfluorophosphate. Proteases, secreted from Bacillus sp., typically have molecular weights ranging from 20,000 to 30,000. They are typically stabilized by Ca2+ and have high isoelectric points. It is highly soluble in detergents at a wide range of pH and temperatures.

Legal Information

A product of Novozyme Corp.
Savinase is a registered trademark of Novozymes Corp.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Yoshifumi Shimada et al.
Human pathology, 66, 1-9 (2017-02-27)
HER2-targeted therapy is considered effective for KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (CRC). In general, HER2 status is determined by the use of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Comprehensive genomic sequencing (CGS) enables the detection
Alessio Gomiero et al.
Environmental science and pollution research international, 26(24), 24407-24416 (2019-06-24)
In recent years, the occurrence of microplastics in the aquatic environment has gathered increasing scientific interest. Several studies have shown that the ingestion of microplastics may negatively influence the physiology of marine organisms having different feeding strategies, particularly in those
Juliana A S Leite et al.
Frontiers in nutrition, 8, 626475-626475 (2021-03-30)
Proteases present in milk are heat-sensitive, and their activities increase or decrease depending on the intensity of the thermal treatment applied. The thermal effects on the protease activity are well-known for bovine milk but poorly understood for ovine and caprine
Vikram Babu Kasaragod et al.
Neuron, 101(4), 673-689 (2019-02-02)
The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however
R Jha et al.
Journal of animal science, 93(3), 1039-1051 (2015-05-29)
Effects of treating corn and wheat distillers dried grains with solubles (DDGS) with a multicarbohydrase alone or in combination with a protease on porcine in vitro fermentation characteristics and the matrix structure of the DGGS before and after the fermentation

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