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Merck

O9637

Sigma-Aldrich

Oxaprozin

solid

Sinónimos:

4,5-Diphenyl-2-oxazolepropanoic acid, Daypro

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About This Item

Fórmula empírica (notación de Hill):
C18H15NO3
Número de CAS:
Peso molecular:
293.32
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

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form

solid

Quality Level

SMILES string

OC(=O)CCc1nc(-c2ccccc2)c(o1)-c3ccccc3

InChI

1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)

InChI key

OFPXSFXSNFPTHF-UHFFFAOYSA-N

Gene Information

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1 of 4

Este artículo
GF44722469GF32887244GF99008972
Aluminum wire reel, 10m, diameter 0.025mm, as drawn, 99.99+%

GF73184924

Aluminum

Aluminum wire reel, 10m, diameter 0.125mm, as drawn, 99.99+%

GF44722469

Aluminum

Aluminum wire reel, 10m, diameter 0.05mm, as drawn, 99.99+%

GF32887244

Aluminum

Aluminum wire reel, 10m, diameter 1.0mm, as drawn, 99.95+%

GF99008972

Aluminum

form

wire

form

wire

form

wire

form

wire

assay

99.99%

assay

99.99%

assay

99.99%

assay

≥99.95%

density

2.7 g/mL at 25 °C (lit.)

density

2.7 g/mL at 25 °C (lit.)

density

2.7 g/mL at 25 °C (lit.)

density

2.7 g/mL at 25 °C (lit.)

resistivity

2.6548 μΩ-cm

resistivity

2.6548 μΩ-cm

resistivity

2.6548 μΩ-cm

resistivity

2.6548 μΩ-cm

bp

2460 °C (lit.)

bp

2460 °C (lit.)

bp

2460 °C (lit.)

bp

2460 °C (lit.)

General description

Oxaprozin is a non-steroidal anti-inflammatory drug prescribed for rheumatoid arthritis (RA) and osteoarthritis (OA).[1] Oxaprozin binds to albumin. It inhibits arachidonic acid pathway.[1] Oxaprozin has anti-inflammatory property and is an effective inhibitor of cyclooxygenase enzymes, COX-1 and COX-2.[2]

Application

Anti-inflammatory

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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    Lot/Batch Number

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    Seda G Sagdinc et al.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 75(4), 1370-1376 (2010-02-20)
    The molecular structure, linear and nonlinear optical properties, and electronic properties of 4,5-diphenyl-2-2 oxazole propionic acid (oxaprozin) as a monomer were investigated by using Hartree-Fock (HF) and density functional theory (DFT) calculations that used 6-31G(d,p) basis set. The first-order hyperpolarizability
    N Bellamy et al.
    Current medical research and opinion, 15(2), 121-127 (1999-09-24)
    Although progress has been made in the clinical metrology of pain in rheumatoid arthritis, much further work remains. The preferred methods of measurement remain debatable. In this longitudinal, open study, a comparison of eight self-rating pain scales has been conducted.
    Barbara Heller et al.
    Current medical research and opinion, 20(8), 1279-1290 (2004-08-25)
    To evaluate the efficacy and safety of oxaprozin in comparison with diclofenac in patients with periarthritis pain of the shoulder previously unsuccessfully treated with nonsteroidal anti-inflammatory drugs other than diclofenac and oxaprozin. In this open, multicentre, randomised, controlled study, eligible
    K V Reddy et al.
    Journal of pharmaceutical and biomedical analysis, 22(4), 651-659 (2000-04-18)
    A reversed phase linear gradient liquid chromatographic method was developed for the separation and quantitative determination of the seven known process related impurities and one degraded product of oxaprozin in the bulk drug material. An Inertsil-ODS 3V (150 x 4.6
    Bojan D J Božić et al.
    Chemical & pharmaceutical bulletin, 60(7), 865-869 (2012-07-14)
    A series of novel Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with oxaprozin (Hoxa), a non-steroidal anti-inflammatory drug, has been synthesized. The drug and complexes have been characterized by elemental and thermogravimetric (TG) analysis, Fourier transform (FT)-IR, 1H-NMR, 13C-NMR, UV-Vis

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