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O2750

Sigma-Aldrich

Orotic acid

≥98% (titration), anhydrous

Sinónimos:

2,6-Dihydroxypyrimidine-4-carboxylic acid, 6-Carboxy-2,4-dihydroxypyrimidine, 6-Carboxyuracil, Uracil-6-carboxylic acid

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About This Item

Fórmula empírica (notación de Hill):
C5H4N2O4
Número de CAS:
65-86-1
Peso molecular:
156.10
Beilstein/REAXYS Number:
383901
EC Number:
200-619-8
MDL number:
MFCD00006027
UNSPSC Code:
41106305
PubChem Substance ID:
24897967
NACRES:
NA.51

grade

anhydrous

Quality Level

200

assay

≥98% (titration)

mp

≥300 °C

SMILES string

OC(=O)C1=CC(=O)NC(=O)N1

InChI

1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)

InChI key

PXQPEWDEAKTCGB-UHFFFAOYSA-N

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Application

Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCQ2243
MKCM3210
MKCK0782
MKCG2160
MKCD0315

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