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N1771

Sigma-Aldrich

nor-Binaltorphimine dihydrochloride

≥98% (TLC), solid, κ-opioid receptor antagonist

Sinónimos:

nor-BNI dihydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C40H43N3O6 · 2HCl
Número de CAS:
113158-34-2
Peso molecular:
734.71
MDL number:
MFCD00069374
UNSPSC Code:
12352200
PubChem Substance ID:
24278018
NACRES:
NA.77

product name

nor-Binaltorphimine dihydrochloride,

form

solid

Quality Level

200

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7[C@@H]8Oc9c(O)ccc%10C[C@H]%11N(CC[C@@]8(c9%10)[C@@]%11(O)Cc7c6C[C@@]35O)CC%12CC%12)CC%13CC%13

InChI

1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1

InChI key

JOJPJLHRMGPDPV-LZQROVCBSA-N

Gene Information

human ... OPRK1(4986)

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Biochem/physiol Actions

Highly selective k-opioid receptor antagonist. nor-Binaltorphimine has antidepressant properties.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: Behavioral and BDNF mRNA expression studies
Zhang H, et al.
European Journal of Pharmacology, 570(1-3), 89-96 (2007)
T K Eisenstein et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1484-1489 (1995-12-01)
An in vitro assay was used to compare the effect of opioids on antibody production by splenocytes from C3HeB/FeJ, C57BL/6J, C57BL/6ByJ and B6C3F1/J mice immunized with sheep red blood cells (SRBC). Spleen cells were removed from mice that had been
Yan Zhang et al.
Neuron, 99(5), 941-955 (2018-08-21)
The gate control theory proposes that Aβ mechanoreceptor inputs to spinal pain transmission T neurons are gated via feedforward inhibition, but it remains unclear how monosynaptic excitation is gated by disynaptic inhibitory inputs that arrive later. Here we report that
J G Wettstein et al.
Pharmacology, biochemistry, and behavior, 53(2), 411-416 (1996-02-01)
The antinociceptive effects of mu and kappa agonists were examined after the systemic administration of the opioid antagonists nor-binaltorphimine (nor-BNI) and naloxone in the late response or tonic nociceptive phase of the mouse formalin assay. Initially, SC morphine (ED50, 0.97
K W Kim et al.
Life sciences, 58(19), 1671-1679 (1996-01-01)
Receptor binding studies were performed to characterize the properties of subtypes of kappa opioid receptors in membrane preparations of human cerebral cortex. [3H]U69,593 ([3H]U69), a selective kappa 1-agonist, and [3H]diprenorphine ([3H]DIP), a non-selective opioid antagonist, in the presence of 1
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