Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

N1537

Sigma-Aldrich

NU7026

≥98% (HPLC), solid

Sinónimos:

2-(Morpholin-4-yl)-benzo[h]chromen-4-one

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C17H15NO3
Número de CAS:
154447-35-5
Peso molecular:
281.31
MDL number:
MFCD06798345
UNSPSC Code:
12352200
PubChem Substance ID:
329818582
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

tan

solubility

DMSO: soluble 3 mg/mL at 60 °C
H2O: insoluble

shipped in

wet ice

storage temp.

2-8°C

SMILES string

O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4

InChI

1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

InChI key

KKTZALUTXUZPSN-UHFFFAOYSA-N

Application

NU7026 has been used:
  • as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
  • in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
  • to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Potent, ATP-competitive. IC50 = 0.23 μM. Selectivity over other PI3K-related kinases (IC50 = 13 μM for PI3K and >100 μM for ATM and ATR).

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Takeshi Yasuda et al.
Genes to cells : devoted to molecular & cellular mechanisms, 26(5), 328-335 (2021-02-25)
SIRT2 and SIRT3 protein deacetylases maintain genome integrity and stability. However, their mechanisms for maintaining the genome remain unclear. To examine the roles of SIRT2 and SIRT3 in DSB repair, I-SceI-based GFP reporter assays for HR, single-strand annealing (SSA) and
Rachel E Doherty et al.
Cancers, 11(9) (2019-09-05)
Uveal melanoma (UM) is the most common primary intraocular tumour in adults, with a mean survival of six months following metastasis. The survival rates have not improved in over 30 years. This study has shown that sister chromatid exchange (SCE)
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo [def, p] chrysene on human hepatocellular cancer cell line HepG2
Spryszynska S, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 791, 12-24 (2015)
Sandra Wimberger et al.
Nature communications, 14(1), 4761-4761 (2023-08-15)
Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended mutations represent major limitations for genome editing applications caused by the
Hideaki Ogiwara et al.
PloS one, 6(12), e28756-e28756 (2011-12-24)
Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double strand break (DSBs) with incompatible DNA ends, which are often generated by ionizing irradiation. In vitro reconstitution studies have indicated that NHEJ of incompatible DNA ends
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico