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N1162

Sigma-Aldrich

NS3763

≥98% (HPLC), solid

Sinónimos:

5-Carboxy-2,4-dibenzamidobenzoic acid

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About This Item

Fórmula empírica (notación de Hill):
C22H16N2O6
Número de CAS:
70553-45-6
Peso molecular:
404.37
MDL number:
MFCD00334657
UNSPSC Code:
12352202
PubChem Substance ID:
24724545
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: ~24 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)c1cc(C(O)=O)c(NC(=O)c2ccccc2)cc1NC(=O)c3ccccc3

InChI

1S/C22H16N2O6/c25-19(13-7-3-1-4-8-13)23-17-12-18(16(22(29)30)11-15(17)21(27)28)24-20(26)14-9-5-2-6-10-14/h1-12H,(H,23,25)(H,24,26)(H,27,28)(H,29,30)

InChI key

UUDYZUDTQPLDDP-UHFFFAOYSA-N

Biochem/physiol Actions

First non-competitive antagonist of GluK5 receptor.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

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Katherine R Schouest et al.
PloS one, 4(10), e7450-e7450 (2009-10-15)
The germinal center kinases (GCK) constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses. Although diverse, these functions have been
Péter Erdélyi et al.
Journal of cell science, 124(Pt 9), 1510-1518 (2011-04-20)
Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells that, depending on the cellular milieu, can either promote survival or act as an alternative mechanism of programmed cell death (PCD) in terminally differentiated cells. Despite the important developmental and medical
Saravanapriah Nadarajan et al.
Development (Cambridge, England), 136(13), 2223-2234 (2009-06-09)
Fertility depends on germline stem cell proliferation, meiosis and gametogenesis, yet how these key transitions are coordinated is unclear. In C. elegans, we show that GLP-1/Notch signaling functions in the germline to modulate oocyte growth when sperm are available for
Katherine Waters et al.
Developmental biology, 344(2), 1011-1025 (2010-07-06)
Proliferating germ cells in Caenorhabditiselegans provide a useful model system for deciphering fundamental mechanisms underlying the balance between proliferation and differentiation. Using gene expression profiling, we identified approximately 200 genes upregulated in the proliferating germ cells of C. elegans. Functional
Peter E A Ash et al.
Human molecular genetics, 19(16), 3206-3218 (2010-06-10)
RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. We have engineered pan-neuronal expression of human TDP-43 protein in Caenorhabditis elegans, with the goal of generating a convenient in vivo model
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