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Merck
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MAK203

Sigma-Aldrich

DPP4 INHIBITOR SCREENING KIT

Sufficient for 100 Fluorometric tests

Sinónimos:

Adenosine Deaminase Complexing Protein-2 Inhibitor Screening Kit, CD26 Inhibitor Screening Kit, Dipeptidyl-Peptidase 4 Inhibitor Screening Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.25

application(s)

pharmaceutical

detection method

fluorometric

relevant disease(s)

endocrinological disorders, diabetes

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... DPP4(1803)
mouse ... DPP4(13482)
rat ... DPP4(25253)

General description

Dipeptidyl-peptidase 4 (DPP4; CD26; adenosine deaminase complexing protein-2) is a membrane glycoprotein with serine exopeptidase activity that cleaves X-proline dipeptides from the N-terminus of polypeptides. Inhibitors of DPP4 inhibit the degradation of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 by DPP4 and have emerged as oral anti-diabetic agents.

Features and Benefits

Compatible with high-throughput handling systems.

Suitability

Suitable for the screening of inhibitors of DPP4.

Principle

The DPP4 Inhibitor Screening Kit is a simple assay suitable for high-throughput screening of potential DPP4 inhibitors. DPP4 activity is measured by cleaving the substrate to yield a fluorescent product (λex = 360/λem = 460 nm), proportional to the enzymatic activity present. The effectiveness of the test inhibitors may be compared with the DPP4 inhibitor (sitagliptin) provided as a control.

Solo componentes del kit

Referencia del producto
Descripción
  • DPP4 Assay Buffer
  • DPP4 Substrate
  • DPP4 Enzyme
  • DPP4 Inhibitor, Sitagliptin

Storage Class

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Paulina Kęska et al.
Nutrients, 14(4) (2022-02-27)
The ability of peptides from an aqueous and salt-soluble protein extract of dry-cured pork loins to inhibit the action of dipeptidyl peptidase IV was determined. This activity was assessed at different times of the production process, i.e., 28, 90, 180

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