M2199

PMEG hydrate

≥98% (HPLC)

• Sinónimos: 9-[2-(Phosphonomethoxy)ethyl]guanine hydrate
• Fórmula empírica (notación de Hill): C₈H₁₂N₅O₅P · xH₂O
• Número de CAS: 1255517-79-3
• Peso molecular: 289.19 (anhydrous basis)
• MDL number: MFCD19443863
• UNSPSC Code: 12352202
• PubChem Substance ID: 329817932
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.NC1=Nc2c(ncn2CCOCP(O)(O)=O)C(=O)N1
• InChI: 1S/C8H12N5O5P.H2O/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17;/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14);1H2
• InChI key: BDVQXHFCXJXVND-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3