M1323

Midostaurin hydrate

≥98% (HPLC), solid, kinase inhibitor

• Sinónimos: CGP 41251, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide, N-benzoylstaurosporine, PKC-412
• Fórmula empírica (notación de Hill): C₃₅H₃₀N₄O₄ · xH₂O
• Número de CAS: 1217450-80-0
• Peso molecular: 570.64 (anhydrous basis)
• MDL number: MFCD12828879
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817870
• NACRES: NA.77

Propiedades

• Nombre del producto: Midostaurin hydrate, ≥98% (HPLC), solid
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• SMILES string: O.CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)[n@@H]3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8[n@H]2c7c35)N(C)C(=O)c9ccccc9
• InChI: 1S/C35H30N4O4.H2O/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38;/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40);1H2/t25-,26-,32-,35+;/m1./s1
• InChI key: YEKDLUZCCDJYAJ-LJAYRLSQSA-N

Descripción

Biochem/physiol Actions

Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF.

Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. Midostaurin inhibits cell growth and phosphorylation of FLT3, STAT5, and ERK. Midostaurin is a potent inhibitor of a spectrum of FLT3 activation loop mutations.

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)