M0252

Methylglyoxal solution

~40% in H₂O

• Sinónimos: Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde
• Fórmula lineal: CH₃COCHO
• Número de CAS: 78-98-8
• Peso molecular: 72.06
• Beilstein/REAXYS Number: 906750
• MDL number: MFCD00006960
• UNSPSC Code: 12352204
• PubChem Substance ID: 24896540
• NACRES: NA.32

Propiedades

• form: liquid
• Quality Level: 200
• concentration: ~40% (enzymatic); ~40% in H₂O
• density: 1.17 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: [H]C(=O)C(C)=O
• InChI: 1S/C3H4O2/c1-3(5)2-4/h2H,1H3
• InChI key: AIJULSRZWUXGPQ-UHFFFAOYSA-N

Descripción

General description

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.

Application

Methylglyoxal solution has been used:

• to assess glyoxalase 1 (GLO1) enzymatic activity
• as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro
• to regulate anxiety like behavior in mice
• to induce peritoneal fibrosis in rats
• to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts
• for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

Información de seguridad

• pictograms: GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H290,H317,H318,H341
• pcodes: P202 - P234 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter