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Merck
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M006

Sigma-Aldrich

Proglumide sodium salt

solid

Sinónimos:

4-Benzoylamino-5-dipropylamino-5-oxopentanoic acid sodium-potassium salt, N-Benzoyl-N′,N′-dipropyl-DL-isoglutamine sodium-potassium salt

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About This Item

Fórmula empírica (notación de Hill):
C18H25N2NaO4
Número de CAS:
99247-33-3
Peso molecular:
356.39
MDL number:
MFCD00069301
UNSPSC Code:
12352200
PubChem Substance ID:
24896533

form

solid

Quality Level

100

color

white

solubility

H2O: soluble

SMILES string

[Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)c1ccccc1

InChI

1S/C18H26N2O4.Na/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14;/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22);/q;+1/p-1

InChI key

UFMWGCINVOIJSO-UHFFFAOYSA-M

Gene Information

human ... CCK(885) , CCKAR(886) , CCKBR(887)
mouse ... CCK(12424)
rat ... CCK(25298)

Application

Proglumide sodium salt has been used to study the effects of proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.

Biochem/physiol Actions

Proglumide sodium salt is a non-peptide cholecystokinin receptor antagonist that has greater selectivity for the CCKA subtype. It selectively blocks central nervous system effects. Proglumide sodium salt is orally active.
CCK antagonist; selectively blocks CNS effects.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

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Sigma-Aldrich

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The cholecystokinin antagonist, proglumide, increases food intake in the rat
G.Shillabeer and J. Davidson
Regulatory Peptides (1984)
J V Menani et al.
The American journal of physiology, 275(5 Pt 2), R1431-R1437 (1998-10-29)
The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II
E S Corp et al.
Physiology & behavior, 61(6), 823-827 (1997-06-01)
Cholecystokinin (CCK) receptors are classified as two subtypes, designated CCK(A) and CCK(B), and both subtypes are found in brain and peripheral tissues of rats. CCK-8 has been shown to act peripherally to reduce meal size, and this satiating action can
Role of cholecystokinin and its antagonist proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.
V. C. Rubio
Physiology & Behavior (2008)
James M Hill et al.
Science translational medicine, 6(265), 265ra169-265ra169 (2014-12-05)
Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals that target viral DNA replication. The initiation of herpes simplex virus infection and reactivation from latency
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