K2389

Ácido kaínico monohydrate

≥98% (HPLC), from Digenea simplex

• Sinónimos: 2-Carboxi-3-carboximetil-4-isopropenilpirrolidina
• Fórmula empírica (notación de Hill): C₁₀H₁₅NO₄ · H₂O
• Número de CAS: 58002-62-3
• Peso molecular: 231.25
• MDL number: MFCD00150833
• UNSPSC Code: 12352106
• PubChem Substance ID: 24724520
• NACRES: NA.77

Propiedades

• biological source: Digenea simplex
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: H₂O: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
• InChI: 1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
• InChI key: FZNZRJRSYLQHLT-SLGZUKMRSA-N

Descripción

Application

Kainic acid monohydrate has been used:

• As a convulsant to induce epileptogenesis and epilepsy in mice.
• To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
• To induce seizures in rat model.
• To induce status epilepticus in adult male Wistar rats.

Biochem/physiol Actions

Agonista de la clase kainato de los receptores ionotrópicos del glutamato

El ácido kaínico monohidratado es un agonista de la clase kainato de los receptores ionotrópicos del glutamato, que induce convulsiones y neurodegeneración in vivo y se utiliza para inducir epilepsia experimental en roedores y para estudiar los mecanismos de apoptosis neuronal inducida por excitación.

Ionotropic glutamate receptors form ion channels, and conduct Na⁺ and K⁺ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)