I9409

Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster

clone 126002, purified immunoglobulin, lyophilized powder

• Sinónimos: Anti-IGF-I
• MDL number: MFCD00162566
• UNSPSC Code: 51111800
• NACRES: NA.41

Propiedades

• biological source: hamster
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 126002, monoclonal
• form: lyophilized powder
• species reactivity: mouse
• technique(s): capture ELISA: 2-8 μg/mL; neutralization: suitable; western blot: 1-2 μg/mL
• isotype: IgG1
• UniProt accession no.: P05017
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Igf1(16000)

Descripción

General description

Insulin-like Growth Factor-I (also known as somatomedinC and somatomedin A) and insulin-like growth factor-II(IGF-II) belong to the family of insulin-like growthfactors, which are structurally homologous to proinsulin.Mature IGF-I and IGF-II are h

Immunogen

purified, E. coli-derived recombinant mouse insulin-like growth factor-I.

Biochem/physiol Actions

Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effects of IGF-1R signaling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)