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H3261

Sigma-Aldrich

2-Mercaptopyridine N-oxide sodium salt

≥96%

Sinónimos:

Sodium Omadine, Sodium pyrithione, 1-Hydroxy-2-pyridinethione sodium salt, 2-Mercaptopyridine-1-oxide sodium salt, 2-Pyridinethiol-1-oxide sodium salt, Pyrithione sodium salt

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About This Item

Fórmula empírica (notación de Hill):
C5H4NNaOS
Número de CAS:
3811-73-2
Peso molecular:
149.15
Beilstein/REAXYS Number:
4026050
EC Number:
223-296-5
MDL number:
MFCD01941547
UNSPSC Code:
51102829
PubChem Substance ID:
24895565
NACRES:
NA.85

biological source

synthetic

Quality Level

200

assay

≥96%

color

faintly beige
 white to light yellow

solubility

H2O: 50 mg/mL

antibiotic activity spectrum

fungi

mode of action

cell membrane | interferes

SMILES string

[Na+].[O-][n+]1ccccc1[S-]

InChI

1S/C5H5NOS.Na/c7-6-4-2-1-3-5(6)8;/h1-4,8H;/q;+1/p-1

InChI key

WNGMMIYXPIAYOB-UHFFFAOYSA-M

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Categorías relacionadas

Application

2-Mercaptopyridine N-oxide can be used to generate bidentate oxothiolane chelates with transition metals.
2-Mercaptopyridine N-oxide, also called pyrithione, is added to cells in culture so metals enter them readily without relying on transporters. It is used to study picornavirus infections.

Biochem/physiol Actions

2-Mercaptopyridine N-oxide is a zinc ionophore that transports zinc into cells.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1

target_organs

Nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCBZ9584
BCBS5803V
BCBR1979V
075M4047V
065M4172V

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Antonia A Nemec et al.
American journal of respiratory cell and molecular biology, 41(1), 69-75 (2008-12-23)
We recently reported that induction of metallothionein (MT) was critical in limiting nickel (Ni)-induced lung injury in intact mice. Nonetheless, the mechanism by which Ni induces MT expression is unclear. We hypothesized that the ability of Ni to mobilize zinc
B M Krenn et al.
Journal of virology, 83(1), 58-64 (2008-10-17)
We have discovered two metal ion binding compounds, pyrithione (PT) and hinokitiol (HK), that efficiently inhibit human rhinovirus, coxsackievirus, and mengovirus multiplication. Early stages of virus infection are unaffected by these compounds. However, the cleavage of the cellular eukaryotic translation
Hui Li et al.
Small (Weinheim an der Bergstrasse, Germany), 15(28), e1901910-e1901910 (2019-06-05)
Birth control and family planning play pivotal roles in the economic growth and reduction of maternal, infant, and child mortality. Current contraceptives, such as hormonal agents and intrauterine devices, target only a small subset of reproductive processes and can have

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