GW22473C
Anti-PRKCQ antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
manufacturer/tradename
Genway 15-288-22473C
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PRKCQ(5588)
General description
PRKCQ (protein kinase C θ) is majorly expressed in T-cells, and is a member of the PKC protein family. It belongs to the subfamily of proteins which are induced by diacylglycerol (DAG), rather than Ca2+. It is the only PKC member that is localized to the immunological synapse.
Application
Anti-PRKCQ antibody produced in chicken is suitbale for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Protein kinase C θ (PKC-θ) promotes epithelial to mesenchymal transition (EMT) by acting as a critical chromatin-anchored switch for inducible genes. Chromatinized PKC-θ exists as an active transcription complex and is essential to establish a permissive chromatin state at signature EMT genes. It plays a central role in TCR-induced IL-2 production and T-cell proliferation. PKCθ activity is regulated by the intracellular redox state. It is the only T cell-expressed PKC that localizes selectively to the center of the immunological synapse (IS) following conventional T cell antigen stimulation. This unique localization is required for PKCθ-mediated downstream signaling. These attributes of PKCθ makes it an attractive target for catalytic or allosteric inhibitors. PKCθ may be associated with type 2 diabetis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Judy L Cannon et al.
PloS one, 8(11), e78940-e78940 (2013-11-20)
Cell motility is a fundamental process crucial for function in many cell types, including T cells. T cell motility is critical for T cell-mediated immune responses, including initiation, activation, and effector function. While many extracellular receptors and cytoskeletal regulators have
Anjum Zafar et al.
Molecular and cellular biology, 34(16), 2961-2980 (2014-06-04)
Epithelial to mesenchymal transition (EMT) is activated during cancer invasion and metastasis, enriches for cancer stem cells (CSCs), and contributes to therapeutic resistance and disease recurrence. Signal transduction kinases play a pivotal role as chromatin-anchored proteins in eukaryotes. Here we
Julia Szendroedi et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9597-9602 (2014-07-01)
Muscle insulin resistance is a key feature of obesity and type 2 diabetes and is strongly associated with increased intramyocellular lipid content and inflammation. However, the cellular and molecular mechanisms responsible for causing muscle insulin resistance in humans are still
Elizabeth Yan Zhang et al.
Advances in pharmacology (San Diego, Calif.), 66, 267-312 (2013-02-26)
Protein kinase C-theta (PKCθ) is a protein kinase C (PKC) family member expressed predominantly in T lymphocytes, and extensive studies addressing its function have been conducted. PKCθ is the only T cell-expressed PKC that localizes selectively to the center of
Marina Rode von Essen et al.
European journal of immunology, 43(6), 1659-1666 (2013-02-26)
PKC-θ plays a central role in TCR-induced IL-2 production and T-cell proliferation. The aim of the present study was to analyse how PKC-θ is regulated in human T cells during T-cell activation and differentiation. We show that PKC-θ is found
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